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PD1-PDL1 Interaction

The antibody-based cancer immunotherapies targeting the Programmed Cell Death1-Programmed Cell Death Ligand 1 (PD1-PDL1) interaction have shown unprecedented clinical success against several types of cancer. We aim to discover small-molecule inhibitors of PD1-PDL1 interaction that may offer several advantages as compared to antibodies, such as higher oral bioavailability, lower cost, better tumor infiltration, and relatively shorter half-life that is especially helpful in controlling any potential adverse immune reactions.

Our Team.

Dedicated Patil Lab members that carried out this cutting-edge research in cancer immunotherapy & beyond!

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